apalutamide will lessen the level or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in reduced publicity to those drugs.cyclophosphamide will raise the amount or impact of modafinil by
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